Thaumatin-like protein and baker's respiratory allergy.
Identifieur interne : 000279 ( Main/Exploration ); précédent : 000278; suivant : 000280Thaumatin-like protein and baker's respiratory allergy.
Auteurs : Maili Lehto [Finlande] ; Liisa Airaksinen ; Anne Puustinen ; Sari Tillander ; Sari Hannula ; Tuula Nyman ; Elina Toskala ; Harri Alenius ; Antti LauermaSource :
- Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology [ 1081-1206 ] ; 2010.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Antigènes végétaux (immunologie), Antigènes végétaux (isolement et purification), Asthme (diagnostic), Asthme (immunologie), Femelle (MeSH), Finlande (MeSH), Humains (MeSH), Hypersensibilité au blé (diagnostic), Hypersensibilité au blé (immunologie), Maladies professionnelles (diagnostic), Maladies professionnelles (immunologie), Manipulation des aliments (MeSH), Myeloperoxidase (immunologie), Myeloperoxidase (isolement et purification), Mâle (MeSH), Protéines de transport (immunologie), Protéines de transport (isolement et purification), Protéines végétales (immunologie), Protéines végétales (isolement et purification), Spectrométrie de masse (MeSH), Tests cutanés (MeSH), Triticum (immunologie).
- MESH :
- diagnostic : Asthme, Hypersensibilité au blé, Maladies professionnelles.
- immunologie : Antigènes végétaux, Asthme, Hypersensibilité au blé, Maladies professionnelles, Myeloperoxidase, Protéines de transport, Protéines végétales, Triticum.
- isolement et purification : Antigènes végétaux, Myeloperoxidase, Protéines de transport, Protéines végétales.
- Adulte, Adulte d'âge moyen, Femelle, Finlande, Humains, Manipulation des aliments, Mâle, Spectrométrie de masse, Tests cutanés.
- Wicri :
- geographic : Finlande.
English descriptors
- KwdEn :
- Adult (MeSH), Antigens, Plant (immunology), Antigens, Plant (isolation & purification), Asthma (diagnosis), Asthma (immunology), Carrier Proteins (immunology), Carrier Proteins (isolation & purification), Female (MeSH), Finland (MeSH), Food Handling (MeSH), Humans (MeSH), Male (MeSH), Mass Spectrometry (MeSH), Middle Aged (MeSH), Occupational Diseases (diagnosis), Occupational Diseases (immunology), Peroxidase (immunology), Peroxidase (isolation & purification), Plant Proteins (immunology), Plant Proteins (isolation & purification), Skin Tests (MeSH), Triticum (immunology), Wheat Hypersensitivity (diagnosis), Wheat Hypersensitivity (immunology).
- MESH :
- chemical , immunology : Antigens, Plant, Carrier Proteins, Peroxidase, Plant Proteins.
- chemical , isolation & purification : Antigens, Plant, Carrier Proteins, Peroxidase, Plant Proteins.
- geographic : Finland.
- diagnosis : Asthma, Occupational Diseases, Wheat Hypersensitivity.
- immunology : Asthma, Occupational Diseases, Triticum, Wheat Hypersensitivity.
- Adult, Female, Food Handling, Humans, Male, Mass Spectrometry, Middle Aged, Skin Tests.
Abstract
BACKGROUND
Baker's asthma and rhinitis are among the most common occupational diseases. Inhaled cereal flours, such as wheat, especially cause this disease.
OBJECTIVE
To identify and test in vivo clinically important wheat allergens in baker's respiratory allergy in a Finnish population.
METHODS
Potential wheat allergens were purified using chromatographic methods from salt-soluble protein extracts of wheat flour and were used in skin prick tests with serial 10-fold dilutions (0.5-0.005 mg/mL). Twenty patients with baker's rhinitis, asthma, or both participated in this study. All the patients had positive skin prick test reactions and specific IgE antibodies to wheat flour. The control group consisted of 10 healthy individuals. Molecular identities of purified wheat allergens were characterized using sodium dodecyl sulfate-polyacrylamide gel electrophoresis and tandem mass spectrometry.
RESULTS
Allergen concentrations of 0.3-0.5 mg/mL revealed that 12 patients reacted to a-amylase inhibitor (alpha-AI), 9 to peroxidase I (PI), 9 to thaumatin-like protein (TLP), and 6 to lipid transfer protein 2G (LTP2G). Conversely, with allergen concentrations of 0.05 mg/mL, 5 patients responded to alpha-AI, 3 to PI, 4 to LTP2G, and 6 to TLP. Of these, TLP and LTP2G are now observed to be new allergens associated with baker's asthma.
CONCLUSIONS
In addition to the earlier-described alpha-AI and PI, TLP and LTP2G are important in vivo wheat allergens in baker's allergies in Finland. Further studies are needed to elucidate the role of these novel wheat allergens in respiratory disorders.
DOI: 10.1016/j.anai.2009.11.062
PubMed: 20306817
Affiliations:
Links toward previous steps (curation, corpus...)
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Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Airaksinen, Liisa" sort="Airaksinen, Liisa" uniqKey="Airaksinen L" first="Liisa" last="Airaksinen">Liisa Airaksinen</name></author><author><name sortKey="Puustinen, Anne" sort="Puustinen, Anne" uniqKey="Puustinen A" first="Anne" last="Puustinen">Anne Puustinen</name></author><author><name sortKey="Tillander, Sari" sort="Tillander, Sari" uniqKey="Tillander S" first="Sari" last="Tillander">Sari Tillander</name></author><author><name sortKey="Hannula, Sari" sort="Hannula, Sari" uniqKey="Hannula S" first="Sari" last="Hannula">Sari Hannula</name></author><author><name sortKey="Nyman, Tuula" sort="Nyman, Tuula" uniqKey="Nyman T" first="Tuula" last="Nyman">Tuula Nyman</name></author><author><name sortKey="Toskala, Elina" sort="Toskala, Elina" uniqKey="Toskala E" first="Elina" last="Toskala">Elina Toskala</name></author><author><name sortKey="Alenius, Harri" sort="Alenius, Harri" uniqKey="Alenius H" first="Harri" last="Alenius">Harri Alenius</name></author><author><name sortKey="Lauerma, Antti" sort="Lauerma, Antti" uniqKey="Lauerma A" first="Antti" last="Lauerma">Antti Lauerma</name></author></analytic><series><title level="j">Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology</title><idno type="ISSN">1081-1206</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Antigens, Plant (immunology)</term><term>Antigens, Plant (isolation & purification)</term><term>Asthma (diagnosis)</term><term>Asthma (immunology)</term><term>Carrier Proteins (immunology)</term><term>Carrier Proteins (isolation & purification)</term><term>Female (MeSH)</term><term>Finland (MeSH)</term><term>Food Handling (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Mass Spectrometry (MeSH)</term><term>Middle Aged (MeSH)</term><term>Occupational Diseases (diagnosis)</term><term>Occupational Diseases (immunology)</term><term>Peroxidase (immunology)</term><term>Peroxidase (isolation & purification)</term><term>Plant Proteins (immunology)</term><term>Plant Proteins (isolation & purification)</term><term>Skin Tests (MeSH)</term><term>Triticum (immunology)</term><term>Wheat Hypersensitivity (diagnosis)</term><term>Wheat Hypersensitivity (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Antigènes végétaux (immunologie)</term><term>Antigènes végétaux (isolement et purification)</term><term>Asthme (diagnostic)</term><term>Asthme (immunologie)</term><term>Femelle (MeSH)</term><term>Finlande (MeSH)</term><term>Humains (MeSH)</term><term>Hypersensibilité au blé (diagnostic)</term><term>Hypersensibilité au blé (immunologie)</term><term>Maladies professionnelles (diagnostic)</term><term>Maladies professionnelles (immunologie)</term><term>Manipulation des aliments (MeSH)</term><term>Myeloperoxidase (immunologie)</term><term>Myeloperoxidase (isolement et purification)</term><term>Mâle (MeSH)</term><term>Protéines de transport (immunologie)</term><term>Protéines de transport (isolement et purification)</term><term>Protéines végétales (immunologie)</term><term>Protéines végétales (isolement et purification)</term><term>Spectrométrie de masse (MeSH)</term><term>Tests cutanés (MeSH)</term><term>Triticum (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Plant</term><term>Carrier Proteins</term><term>Peroxidase</term><term>Plant Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antigens, Plant</term><term>Carrier Proteins</term><term>Peroxidase</term><term>Plant Proteins</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Finland</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Asthma</term><term>Occupational Diseases</term><term>Wheat Hypersensitivity</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Asthme</term><term>Hypersensibilité au blé</term><term>Maladies professionnelles</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes végétaux</term><term>Asthme</term><term>Hypersensibilité au blé</term><term>Maladies professionnelles</term><term>Myeloperoxidase</term><term>Protéines de transport</term><term>Protéines végétales</term><term>Triticum</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Asthma</term><term>Occupational Diseases</term><term>Triticum</term><term>Wheat Hypersensitivity</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Antigènes végétaux</term><term>Myeloperoxidase</term><term>Protéines de transport</term><term>Protéines végétales</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Food Handling</term><term>Humans</term><term>Male</term><term>Mass Spectrometry</term><term>Middle Aged</term><term>Skin Tests</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Finlande</term><term>Humains</term><term>Manipulation des aliments</term><term>Mâle</term><term>Spectrométrie de masse</term><term>Tests cutanés</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Finlande</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Baker's asthma and rhinitis are among the most common occupational diseases. Inhaled cereal flours, such as wheat, especially cause this disease.</p></div><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>To identify and test in vivo clinically important wheat allergens in baker's respiratory allergy in a Finnish population.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Potential wheat allergens were purified using chromatographic methods from salt-soluble protein extracts of wheat flour and were used in skin prick tests with serial 10-fold dilutions (0.5-0.005 mg/mL). Twenty patients with baker's rhinitis, asthma, or both participated in this study. All the patients had positive skin prick test reactions and specific IgE antibodies to wheat flour. The control group consisted of 10 healthy individuals. Molecular identities of purified wheat allergens were characterized using sodium dodecyl sulfate-polyacrylamide gel electrophoresis and tandem mass spectrometry.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Allergen concentrations of 0.3-0.5 mg/mL revealed that 12 patients reacted to a-amylase inhibitor (alpha-AI), 9 to peroxidase I (PI), 9 to thaumatin-like protein (TLP), and 6 to lipid transfer protein 2G (LTP2G). Conversely, with allergen concentrations of 0.05 mg/mL, 5 patients responded to alpha-AI, 3 to PI, 4 to LTP2G, and 6 to TLP. Of these, TLP and LTP2G are now observed to be new allergens associated with baker's asthma.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>In addition to the earlier-described alpha-AI and PI, TLP and LTP2G are important in vivo wheat allergens in baker's allergies in Finland. Further studies are needed to elucidate the role of these novel wheat allergens in respiratory disorders.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20306817</PMID><DateCompleted><Year>2010</Year><Month>05</Month><Day>24</Day></DateCompleted><DateRevised><Year>2010</Year><Month>03</Month><Day>23</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1081-1206</ISSN><JournalIssue CitedMedium="Print"><Volume>104</Volume><Issue>2</Issue><PubDate><Year>2010</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology</Title><ISOAbbreviation>Ann Allergy Asthma Immunol</ISOAbbreviation></Journal><ArticleTitle>Thaumatin-like protein and baker's respiratory allergy.</ArticleTitle><Pagination><MedlinePgn>139-46</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.anai.2009.11.062</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Baker's asthma and rhinitis are among the most common occupational diseases. Inhaled cereal flours, such as wheat, especially cause this disease.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To identify and test in vivo clinically important wheat allergens in baker's respiratory allergy in a Finnish population.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Potential wheat allergens were purified using chromatographic methods from salt-soluble protein extracts of wheat flour and were used in skin prick tests with serial 10-fold dilutions (0.5-0.005 mg/mL). Twenty patients with baker's rhinitis, asthma, or both participated in this study. All the patients had positive skin prick test reactions and specific IgE antibodies to wheat flour. The control group consisted of 10 healthy individuals. Molecular identities of purified wheat allergens were characterized using sodium dodecyl sulfate-polyacrylamide gel electrophoresis and tandem mass spectrometry.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Allergen concentrations of 0.3-0.5 mg/mL revealed that 12 patients reacted to a-amylase inhibitor (alpha-AI), 9 to peroxidase I (PI), 9 to thaumatin-like protein (TLP), and 6 to lipid transfer protein 2G (LTP2G). Conversely, with allergen concentrations of 0.05 mg/mL, 5 patients responded to alpha-AI, 3 to PI, 4 to LTP2G, and 6 to TLP. Of these, TLP and LTP2G are now observed to be new allergens associated with baker's asthma.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In addition to the earlier-described alpha-AI and PI, TLP and LTP2G are important in vivo wheat allergens in baker's allergies in Finland. Further studies are needed to elucidate the role of these novel wheat allergens in respiratory disorders.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lehto</LastName><ForeName>Maili</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Unit of Excellence for Immunotoxicology, Finnish Institute of Occupational Health, Helsinki, Finland. maili.lehto@ttl.fi</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Airaksinen</LastName><ForeName>Liisa</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Puustinen</LastName><ForeName>Anne</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Tillander</LastName><ForeName>Sari</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Hannula</LastName><ForeName>Sari</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Nyman</LastName><ForeName>Tuula</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Toskala</LastName><ForeName>Elina</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Alenius</LastName><ForeName>Harri</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Lauerma</LastName><ForeName>Antti</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Ann Allergy Asthma Immunol</MedlineTA><NlmUniqueID>9503580</NlmUniqueID><ISSNLinking>1081-1206</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D052179">Antigens, Plant</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002352">Carrier Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010940">Plant Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C060586">WDAI-3 protein, Triticum aestivum</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C511920">lipid transfer proteins, plant</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C549514">thaumatin-like protein, wheat</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.11.1.7</RegistryNumber><NameOfSubstance UI="D009195">Peroxidase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D052179" MajorTopicYN="N">Antigens, Plant</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001249" MajorTopicYN="N">Asthma</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002352" MajorTopicYN="N">Carrier Proteins</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005387" MajorTopicYN="N" Type="Geographic">Finland</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005511" MajorTopicYN="N">Food Handling</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013058" MajorTopicYN="N">Mass Spectrometry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009784" MajorTopicYN="N">Occupational Diseases</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009195" MajorTopicYN="N">Peroxidase</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010940" MajorTopicYN="N">Plant Proteins</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012882" MajorTopicYN="N">Skin Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014908" MajorTopicYN="N">Triticum</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D021182" MajorTopicYN="N">Wheat Hypersensitivity</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>3</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>3</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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sort="Nyman, Tuula" uniqKey="Nyman T" first="Tuula" last="Nyman">Tuula Nyman</name><name sortKey="Puustinen, Anne" sort="Puustinen, Anne" uniqKey="Puustinen A" first="Anne" last="Puustinen">Anne Puustinen</name><name sortKey="Tillander, Sari" sort="Tillander, Sari" uniqKey="Tillander S" first="Sari" last="Tillander">Sari Tillander</name><name sortKey="Toskala, Elina" sort="Toskala, Elina" uniqKey="Toskala E" first="Elina" last="Toskala">Elina Toskala</name></noCountry><country name="Finlande"><noRegion><name sortKey="Lehto, Maili" sort="Lehto, Maili" uniqKey="Lehto M" first="Maili" last="Lehto">Maili Lehto</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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